Substrate: Presenilin 2 (Integral membrane protein)
Seq-ID: P49810 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13995   FLNA_HUMAN
MINT-14380   FLNB_HUMAN
MINT-14946   B2CL1_HUMAN
MINT-16271   FHL2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding centrosome,
Golgi membrane,
nuclear inner membrane,
integral to plasma membrane,
kinetochore,
endoplasmic reticulum membrane		 induction of apoptosis by extracellular signals,
membrane protein ectodomain proteolysis,
apoptosis,
Notch receptor processing,
membrane protein intracellular domain proteolysis,
positive regulation of catalytic activity,
Notch signaling pathway,
amyloid precursor protein catabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 7     MLTFMASDSEEEVCDER CK2_group 8972483
LTP
0.11
 MOD_CK2_1
 - -
0.52
 - medium
S 7     MLTFMASDSEEEVCDER CK1_group 8972483
LTP
0.11
 MOD_CK2_1
 - -
0.52
 - medium
S 7     MLTFMASDSEEEVCDER CK2_alpha 8972483
LTP
0.11
 MOD_CK2_1
 - -
0.52
 - medium
S 9   MLTFMASDSEEEVCDERTS CK2_group 8972483
LTP
0.94
 MOD_CK2_1
 - -
0.53
 - medium
S 9   MLTFMASDSEEEVCDERTS CK1_group 8972483
LTP
0.94
 MOD_CK2_1
 - -
0.53
 - medium
S 9   MLTFMASDSEEEVCDERTS CK2_alpha 8972483
LTP
0.94
 MOD_CK2_1
 - -
0.53
 - medium
S 19 SEEEVCDERTSLMSAESPTPR CK2_group 8972483
LTP
0.25
 MOD_CK1_1
 - -
0.72
 - medium
S 19 SEEEVCDERTSLMSAESPTPR CK1_group 8972483
LTP
0.25
 MOD_CK1_1
 - -
0.72
 - medium
S 25 DERTSLMSAESPTPRSCQEGR - 18669648
HTP
0.94
 - -
0.73
 - medium
S 327 LPYDPEMEEDSYDSFGEPSYP - 9990034
LTP
0.05
 MOD_CK1_1
 - PSN
0.37
 - medium
S 327 LPYDPEMEEDSYDSFGEPSYP CK1_delta 9558331
LTP
0.05
 MOD_CK1_1
 - PSN
0.37
 - medium
S 330 DPEMEEDSYDSFGEPSYPEVF - 9990034
LTP
0.14
 MOD_CK1_1
 - PSN
0.39
 - medium
S 330 DPEMEEDSYDSFGEPSYPEVF CK1_delta 9558331
LTP
0.14
 MOD_CK1_1
 - PSN
0.39
 - medium
S 330 DPEMEEDSYDSFGEPSYPEVF CK2_alpha 9558331
LTP
0.14
 MOD_CK1_1
 - PSN
0.39
 - medium
S 335 EDSYDSFGEPSYPEVFEPPLT CK2_group 9558331
LTP
0.06
 MOD_CK2_1
 - PSN
0.30
 - medium
S 335 EDSYDSFGEPSYPEVFEPPLT CK2_alpha 9558331
LTP
0.06
 MOD_CK2_1
 - PSN
0.30
 - medium

Substrate: Presenilin 2 (Integral membrane protein)
Seq-ID: Q61144 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
endopeptidase activity,
protein binding		 neuronal cell body,
cytosol,
integral to plasma membrane,
endoplasmic reticulum membrane,
Z disc,
Golgi membrane,
membrane fraction		 beta-amyloid metabolic process,
locomotion,
apoptosis,
thymus development,
brain morphogenesis,
protein transport,
regulation of epidermal growth factor receptor activity,
positive regulation of catalytic activity,
regulation of synaptic plasticity,
T cell activation involved in immune response,
hemopoietic progenitor cell differentiation,
positive regulation of apoptosis,
Notch signaling pathway,
anagen,
positive regulation of coagulation,
cardiac muscle contraction,
calcium ion transport,
cell fate specification,
memory,
T cell receptor signaling pathway,
myeloid leukocyte differentiation,
embryonic limb morphogenesis,
lung alveolus development,
forebrain development,
protein maturation by peptide bond cleavage,
somitogenesis,
negative regulation of protein amino acid phosphorylation,
negative regulation of apoptosis,
membrane protein ectodomain proteolysis,
dorsal/ventral neural tube patterning
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 25 DERTSLMSAESPTSRSCQEGR - 19144319
HTP
0.94
 - -
0.68
 - medium
S 30 LMSAESPTSRSCQEGRPGPED - 19144319
HTP
0.92
 - -
0.83
 - medium
S 52 ESTAQWRTQESEEDCEEDPDR - 17242355
HTP
0.30
 - -
0.73
 - medium
S 52 ESTAQWRTQESEEDCEEDPDR - 19144319
HTP
0.30
 - -
0.73
 - medium

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